Myriad Genetics Announces Reorganization of European Operations and Sale of EndoPredict Business – Read more
Homologous recombination deficiency (HRD) testing is key to guiding precision medicine decisions for women with ovarian cancer.1 Now, one real-world study has validated the use of Myriad Genetics’ MyChoice CDx Plus HRD Companion Diagnostic Test in a decentralized setting2, potentially broadening access to crucial genetic insights for more patients worldwide.
"High concordance of the Myriad GIS in a local laboratory is an important milestone to optimize access for both patients and physicians to the gold standard assay."
— Sylvette Delee, M.D., Director of International Medical Affairs, Myriad Genetics
Published in the Journal of Molecular Diagnostics, the study by Denkert et al. compared HRD status and genomic instability score (GIS) results from over 500 tumor samples assessed in parallel at the Philipps-Universität Marburg lab and the central diagnostic lab of Myriad Genetics in Salt Lake City, U.S.
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1. Ray-Coquard, Isabelle et al. “Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer” New England Journal of Medicine vol.381, no 25., 2019, pp. 2416-2428. 2. Denkert, Carsten, et al. “Homologous Recombination Deficiency as an Ovarian Cancer Biomarker in a Real-World Cohort.” The Journal of Molecular Diagnostics, vol. 24, no. 12, 2022, pp. 1254–1263.