Finding patients at risk for adenomatous polyposis syndromes and following up with them is perhaps the most critical step in changing hereditary cancer outcomes. The following indicators* in a patient’s personal or family history indicate an increased risk for a germline mutation in APC or MYH and help determine appropriate candidates for testing:
- Individuals clinically affected with FAP (100 or more colorectal adenomas)
- Individuals with multiple colorectal adenomas (usually 10 or more cumulative adenomas)
- Relatives of APC or MYH mutation carriers
* Assessment criteria based on scientific literature and expert opinion. For a list of references, please visit the reference page.