Individuals with a personal history of, or a close blood relative (1st, 2nd or 3rd degree in the maternal or paternal lineage) with, any one of the Indicators are at increased risk of HBOC. Further clinical evaluation by a qualified healthcare professional to determine the appropriateness of genetic testing is warranted. “Breast cancer” includes both invasive cancer and ductal carcinoma in situ (DCIS). “Ovarian cancer” includes epithelial ovarian cancer, fallopian tube cancer and primary peritoneal cancer.
Indicators are based on medical society guidelines; for these individual societal guidelines, please visit our guidelines page. Indicators are not intended to be used as a guide for insurance coverage purposes.
Personal and/or family history+ of:
- Ovarian cancer 68-70
- Breast cancer diagnosed before age 50 71-76
- Two primary breast cancers* 77-80,245-246
- Male breast cancer 247-249
- Triple Negative Breast Cancer 250-254
- Ashkenazi Jewish ancestry with an HBOC-associated cancer*^ 268-274
- Three or more HBOC-associated cancers at any age*^
- A previously identified HBOC syndrome mutation in the family 275-279
*In the same individual or on the same side of the family
^HBOC-associated cancers include breast (including DCIS), ovarian and pancreatic, and aggressive prostate cancer (Gleason score of >7).
+ Close blood relatives include first, second, or third degree in the maternal or paternal lineage.
**Assessment criteria based on medical society guidelines. For these individual medical society guidelines, go to references