Lynch Syndrome and MAP Cancer Risks

Individuals with Lynch syndrome have an increased risk of colorectal cancer – at least 25% by age 50 and up to 82% by age 70 and a risk of up to 90% to develop some type of cancer.47,48 The risk for certain other cancers, primarily endometrial (up to 71%), ovarian (up to 12%) and gastric (up to 13%) is also increased in Lynch syndrome.  Mutation carriers previously diagnosed with cancer also have a significantly increased risk of developing a second primary (new) cancer of up to 50% within 15 years of the first diagnosis.49 Patients who have MYH-associated polyposis (MAP) have up to an 80% risk of developing colorectal cancer.281

Genetic testing identifies patients who have germline mutations in the genes responsible for Lynch syndrome and MAP.  This information is useful when developing risk-reducing strategies for these patients.