Finding patients who have germline mutations in the PALB2 and BRCA2 genes may provide valuable information about cancer risks to patients and their family members. The following Indicators in a patient’s personal or family history may indicate an increased risk for a PALB2 or BRCA2 mutation. Indicators identify patients at risk for a PALB2 or BRCA2 mutation, for whom further clinical evaluation to determine appropriateness of genetic testing is warranted.
- Pancreatic cancer patient with at least one close relative* with pancreatic cancer163-168
- Individual with two or more close relatives* with pancreatic cancer
- Individual of Ashkenazi Jewish ancestry with a personal history of pancreatic cancer or a first-degree relative* with pancreatic cancer169-171
- A previously identified PALB2 or BRCA2 mutation in the family172-178
* Close refers to first- or second-degree relatives First-degree relatives include parents, siblings, children; second-degree relatives include grandparents, aunts/uncles, nieces/nephews
^ Assessment criteria based on scientific literature and expert opinion. For a list of references, go references