Managing Patients with Hereditary Melanoma Syndrome

If the MELARIS® test shows an increased risk for melanoma and pancreatic cancer, the following medical management options may help reduce that risk.*


Increased Surveillance

  • Monthly self skin exams by patients beginning in childhood133,134
  • Clinical full-body skin exams every 6 to 12 months, beginning at age 10133,134,135,136
  • Baseline whole-body photography every 6 to 12 months beginning at age 10133-137

Preventive Surgery

  • Immediate biopsy and/or removal of suspicious moles133,136,138
  • Lower threshold to biopsy of suspicious moles136,138

Preventive Lifestyle Adjustments

  • Limited exposure to the sun or ultraviolet radiation (e.g., tanning beds)133,136,138
  • Protective clothing, such as wide-brimmed hats, sunglasses, and long-sleeved shirts133,136,138
  • Application of sunscreen with a sun protection factor (SPF) of 15 or higher at regular intervals, especially in young children133,136,138


Increased Surveillance

  • Consider endoscopic ultrasound (EUS), computed tomography (CT), or endoscopic retrograde cholangiopancreatography (ERCP) OR136,139-141
  • Referral to research screening protocols

* Any discussion of medical management options is for general informational purposes only and does not constitute a recommendation. While genetic testing and medical society guidelines provide important and useful information, medical management decisions should be made based on consultation between each patient and his or her healthcare provider.