Individuals with a personal history of, or a close blood relative (1st, 2nd or 3rd degree in the maternal or paternal lineage) with, any one of the Indicators are at increased risk of HBOC. Further clinical evaluation by a qualified healthcare professional to determine the appropriateness of genetic testing is warranted. « Breast cancer » includes both invasive cancer and ductal carcinoma in situ (DCIS). « Ovarian cancer » includes epithelial ovarian cancer, fallopian tube cancer and primary peritoneal cancer.
Indicators are based on medical society guidelines; for these individual societal guidelines, please visit our guidelines page. Indicators are not intended to be used as a guide for insurance coverage purposes.
Personal and/or family history+ of:
- Ovarian cancer 68-70
- Breast cancer diagnosed before age 50 71-76
- Two primary breast cancers* 77-80,245-246
- Male breast cancer 247-249
- Triple Negative Breast Cancer 250-254
- Ashkenazi Jewish ancestry with an HBOC-associated cancer*^ 268-274
- Three or more HBOC-associated cancers at any age*^
- A previously identified HBOC syndrome mutation in the family 275-279
*In the same individual or on the same side of the family
^HBOC-associated cancers include breast (including DCIS), ovarian and pancreatic, and aggressive prostate cancer (Gleason score of >7).
+ Close blood relatives include first, second, or third degree in the maternal or paternal lineage.
**Assessment criteria based on medical society guidelines. For these individual medical society guidelines, go to references