Identifying HBOC Patients

Individuals with a personal history of, or a close blood relative (1st, 2nd or 3rd degree in the maternal or paternal lineage) with, any one of the Indicators are at increased risk of HBOC.  Further clinical evaluation by a qualified healthcare professional to determine the appropriateness of genetic testing is warranted.  « Breast cancer » includes both invasive cancer and ductal carcinoma in situ (DCIS).  « Ovarian cancer » includes epithelial ovarian cancer, fallopian tube cancer and primary peritoneal cancer.

Indicators are based on medical society guidelines; for these individual societal guidelines, please visit our guidelines page.  Indicators are not intended to be used as a guide for insurance coverage purposes.

Personal and/or family history+ of:

  • Ovarian cancer 68-70
  • Breast cancer diagnosed before age 50 71-76
  • Two primary breast cancers* 77-80,245-246
  • Male breast cancer 247-249
  • Triple Negative Breast Cancer 250-254
  • Ashkenazi Jewish ancestry with an HBOC-associated cancer*^ 268-274
  • Three or more HBOC-associated cancers at any age*^
  • A previously identified HBOC syndrome mutation in the family 275-279

*In the same individual or on the same side of the family

^HBOC-associated cancers include breast (including DCIS), ovarian and pancreatic, and aggressive prostate cancer (Gleason score of >7).

+ Close blood relatives include first, second, or third degree in the maternal or paternal lineage.

**Assessment criteria based on medical society guidelines. For these individual medical society guidelines, go to references