Identifying Patients at Risk for Adenomatous Polyposis Syndromes

Finding patients at risk for adenomatous polyposis syndromes and following up with them is perhaps the most critical step in changing hereditary cancer outcomes.  The following indicators* in a patient’s personal or family history indicate an increased risk for a germline mutation in APC or MYH and help determine appropriate candidates for testing:

  • Individuals clinically affected with FAP (100 or more colorectal adenomas)
  • Individuals with multiple colorectal adenomas (usually 10 or more cumulative adenomas)
  • Relatives of APC or MYH mutation carriers

 

* Assessment criteria based on scientific literature and expert opinion. For a list of references, please visit the reference page.