Identifying Patients at Risk for Hereditary Pancreatic Cancer

Finding patients who have germline mutations in the PALB2 and BRCA2 genes may provide valuable information about cancer risks to patients and their family members.  The following Indicators in a patient’s personal or family history may indicate an increased risk for a PALB2 or BRCA2 mutation.  Indicators identify patients at risk for a PALB2 or BRCA2 mutation, for whom further clinical evaluation to determine appropriateness of genetic testing is warranted.

  • Pancreatic cancer patient with at least one close relative* with pancreatic cancer163-168
  • Individual with two or more close relatives* with pancreatic cancer
  • Individual of Ashkenazi Jewish ancestry with a personal history of pancreatic cancer or a first-degree relative*  with pancreatic cancer169-171
  • A previously identified PALB2 or BRCA2 mutation in the family172-178

* Close refers to first- or second-degree relatives First-degree relatives include parents, siblings, children; second-degree relatives include grandparents, aunts/uncles, nieces/nephews

^ Assessment criteria based on scientific literature and expert opinion. For a list of references, go references